Epstein-Barr virus: stimulation by 5'-iododeoxyuridine or 5'-bromodeoxyuridine in human lymphoblastoid cells from a rhabdomyosarcoma.

Epstein-Barr virus was observed by electron microscopy in human lympho­ blastoid cells derived from a rhabdomyosarcoma. Replication of virus particles was stimulated approximately 1 0 fold after treatment of the cells with either 5'-iododeoxyuridine or 5'-bromodeoxyuridine. The evidence supports the con­ cept that the entire Epstein-Barr virus genome persists in some cells of this type. The data also are consistent with the notion that this type cell cannot grow in continuous culture unless they carry at least part of the Epstein-Barr virus genome.